منابع مشابه
Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not intervened, will eventually be followed by appearance of frank diabetes. The mechanisms of this chronic pathogenic process are complex but have been suggested to involve production of reactive oxygen species (ROS) and oxidative stress. In thi...
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To investigate the effects of the predominant nonprotein thiol, glutathione (GSH), on redox homeostasis, we employed complementary pharmacological and genetic strategies to determine the consequences of both loss- and gain-of-function GSH content in vitro. We monitored the redox events in the cytosol and mitochondria using reduction-oxidation sensitive green fluorescent protein (roGFP) probes a...
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Normal cellular functions essentially depend on a balanced redox environment. Free radicals and nonradical oxidants can shift the redox balance toward a more “oxidized” state, which is counteracted by the intracellular antioxidant defense systems. These include the enzymes superoxide dismutase and catalase, as well as the thiol-reducing systems (glutathione, glutaredoxin, and thioredoxin). Glut...
متن کاملHuman serum albumin modifications associated with reductive radical stress.
Radiation-induced modifications of human serum albumin mainly occurring at S-containing residues were investigated by Raman spectroscopy and mass spectrometry techniques. When HO˙ radicals were scavenged by t-BuOH, the H˙ atom and hydrated electron (e(aq)(-)) attack led to the chemical transformation of Cys into Ala residues and the conversion of Met residues into α-aminobutyric acid residues. ...
متن کاملReductive stress after exercise: The issue of redox individuality
Exercise has been consistently used as an oxidant stimulus in redox biology studies. However, previous studies have focused on group differences and did not examine individual differences. As a result, it remains untested whether all individuals experience oxidative stress after acute exercise. Therefore, the main aim of the present study was to investigate whether some individuals exhibit unex...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2010
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.110.153296